The Second IEEE Conference on Telepresence, TELEPRESENCE 2025, will be held 8-10 September 2025, in Leiden, The Netherlands. The conference will provide a stimulating forum for researchers, educators, and practitioners to learn, share knowledge, report the most recent innovations and developments, and exchange ideas and advances in all aspects of telepresence systems and applications, telerobotics, haptics, human-machine interfaces, learning from humans, and autonomy. Integrative approaches are particularly welcome. TELEPRESENCE 2025 will include keynotes by Prof. Thomas B. Sheridan, Dr. Serena Ivaldi, Dr. Jessica Grenouilleau and Prof. Darwin G. Caldwell, industry panels, special sessions, and exhibits to enrich fruitful discussions. In addition to impactful technical interactions, Leiden offers attendees significant opportunities for social and cultural interactions as well as the opportunity for a Technical Tour of the European Space Research and Technology Center (ESTEC).